Overall meaning :
Will those who deny Allah’s revelations and signs not reflect, then, on what Muhammad, may Allah bless him and grant him peace, has brought them—for they are not ignorant of his true character and demeanour—and realise that there he is by no means mad but one who gives clear warning?
Will they not ponder upon the kingdom of the heavens and the earth and all the things that Allah has created in them to realise that He is the sole Creator and disposer of all affairs who alone is deserving of worship, and to see that the end of their time might be near so that they may take heed and hasten to repent? In what message after the Qur’an would they then believe?
None can guide those whom Allah leads astray, and He leaves them wander blindly in their unbelief, plunged in utter confusion, without ever being guided to the truth.